Plants are utilized globally as herbal medicine due to their therapeutic values. Screening of plants for biologically active lead compounds against human pathogens is a renewed interested research in pharmaceutical science. In this study, Aegle marmelos a medicinal plant was evaluated in terms of in vitro microbicidal potentiality against selected bacteria such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Bacillus subtilis. The antibacterial activity of Aegle marmelos leaf extract was studied by agar diffusion method. The methanol leaf extracts showed maximum activity against Klebsiella pneumoniae, with the maximum diameter of zone of inhibition (32 mm), followed by Escherichia coli (20mm) and Staphyllococcus aureus (17mm). The antibacterial activity was minimum against Bacillus subtilis (10mm). Antimicrobial activity of leaf extract is due to the presence of bioactive components such as alkaloids, terpenoids, saponins, tannins, flavonoids and steroids.
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