Since ancient times, the alleviating powers of medicinal plants have been explored for the development of new drugs. Vernonia amygdalina is woody shrub belonging to the Asteraceae family which is reported to have diverse therapeutic effects. Extracts of the plant have been used in various folk medicines as remedies against bacterial and helminthic infections. This research was carried out on the methanolic extract of Vernonia amygdalina to estimate its phytoconstituents, isolate coumarin from the crude extract and evaluate the in vitro antioxidant activity. The phytochemical screening showed the presence of alkaloids, carbohydrates, glycosides, phenols, tannins and coumarin. Antioxidant assays showed significant levels of activity. Vernonia amygdalina and Coumarin were evaluated for the cytotoxicity towards MCF-7 cell lines. Results observed indicated that the extracted coumarin possesses higher activity when compared to Vernonia amygdalina.
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