Background: The adverse effect of smoking is well known and documented. Chronic smokers are prone to develop Ventricular tachyarrhymia & sudden cardiac death due to prolonged QT dispersion. Prolonged QT dispersion is a marker of an inhomogeneity of ventricular repolarization leading to ventricular arrhythmia. One of the important cause of prolonged QT dispersion is ischemic changes due to atherosclerosis of the coronary vessels. Dyslipidemia is the prime cause of atherosclerosis of the coronary vessels. Therefore the present study was conducted to find the correlation between Dyslipidemia & prolonged QT dispersion. Methods: Study group consisted of 75 chronic smokers smoking 10-20 cigarettes/day since five years which were compared with 75 age & sex matched nonsmokers. Vital parameters & 12 lead ECG was recorded from 150 subjects. Heart rate, QT interval, corrected QT interval, QT dispersion was calculated from ECG. , Lipid profile was measured by collecting 12 hours fasting blood samples by enzymatic colorimetric method. Results: There was statistically significant increase in lipid profile parameters like total cholesterol, LDL, triglycerides, LDL :HDL & total cholesterol :HDL ratio & decrease in HDL level in smokers compared to nonsmokers (p<0.001) . Statistically significant increase in QT dispersion in smokers (p<0.05) compared to nonsmokers. There was positive correlation between total cholesterol, LDL & HDL cholesterol & prolonged QT dispersion. Conclusion: Smoking is associated with life threatening tachyarrhythmia & sudden cardiac death due to prolonged QT dispersion. The cause for tachyarrhythmia & sudden cardiac death is due to dyslipidemia leading to prolonged QT dispersion. It has been suggested that prolonged QT dispersion is due to dyslipidemia induced ischemic changes of the coronary vessels.
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